targeting the root of innate immunity

Related Sciences (RS) is a data-driven drug discovery studio. RS uses a proprietary machine learning platform to identify the best new drug discovery opportunities for every disease, organizes them into structured investment portfolios, and then operates them leanly over a specialized platform designed to take full advantage of the last decade's transformational R&D and productivity innovations.

Company at-a-Glance

Biology

Approximately 250 million target-disease pairs collectively represent the current solution space to treat, prevent, and cure all diseases. Choosing among them into which to invest significant research effort and capital is the hard part.

Therapeutic Strategies

At every step in the R&D funnel, a program's unique attributes matched to the historical success rates of programs with similar attributes, roughly inform its odds of advancing or failing.

Portfolio

A wide range of new opportunities exist to capture greater efficiencies in the way biotechs are staffed and operate.

Scientific Leadership

Over the last decade, as pharma companies shuttered major R&D centers, a flood of talented scientists made their way into contract research organizations, broadening their capabilities. Today this "virtual R&D economy" is flourishing, having matured into a wide range of large scale, fully-integrated, multi-modality, high quality R&D providers and a large ecosystem of smaller technology enabled specialist firms, on offer to biotech companies everywhere.

Ranking & Evidence

Over the last decade, as pharma companies shuttered major R&D centers, a flood of talented scientists made their way into contract research organizations, broadening their capabilities.

R&D Partners

Over the last decade, as pharma companies shuttered major R&D centers, a flood of talented scientists made their way into contract research organizations, broadening their capabilities.

Biology

The Powerful Alarm System Inside of Every Cell

Mission-critical systems biology

RS is led by a multi-disciplinary team of drug discovery, data science, and venture capital veterans who have founded, built, and led biotech companies worth billions. The internal RS leadership team plays three important roles: 1) They lead end-to-end drug discovery for all RS companies and their drug programs; 2) They assemble and manage large teams of external researchers and drug discovery specialists; and 3) They build and lead valuable research and technology platform capabilities designed to empower all RS companies.

Danger Detection

Infections
Injuries
Malfunctions
Intracellular
Alarm System
Cytokine Alarms,
Cell Death Programs
Danger Response
Immune
Responses
Immune
Responses
Innate
Immunity
Adaptive
Immunity

A Carefully Balanced System

The 4 processes of danger biology

RS is led by a multi-disciplinary team of drug discovery, data science, and venture capital veterans who have founded, built, and led biotech companies worth billions. The internal RS leadership team plays three important roles: 1) They lead end-to-end drug discovery for all RS companies and their drug programs; 2) They assemble and manage large teams of external researchers and drug discovery specialists; and 3) They build and lead valuable research and technology platform capabilities designed to empower all RS companies.

Activate Immunity Against Cellular Threats
1
Detection
Systems of intracellular sensors detect diverse threats, triggering alarms
2
Response
Cytokine alarms activate innate immune responses and changes to local cell states
Activate Immunity Against Cellular Threats
3
Shut Down
All immune responses are quickly shut down once the threat is resolved
4
Clean Up
Byproducts from self are cleared out or altered to avoid triggering danger sensors
Optimal Immune Responses to Danger

Imbalances Potently Drive Immune-Mediated Diseases

Three key types of imbalances

RS is led by a multi-disciplinary team of drug discovery, data science, and venture capital veterans who have founded, built, and led biotech companies worth billions. The internal RS leadership team plays three important roles: 1) They lead end-to-end drug discovery for all RS companies and their drug programs; 2) They assemble and manage large teams of external researchers and drug discovery specialists; and 3) They build and lead valuable research and technology platform capabilities designed to empower all RS companies.

Imbalanced Immune Responses to Danger
Too much immune activation leads to autoimmune diseases
Unresolved immunity leads to chronic inflammation, immunosuppression, and immune exhaustion
Not enough immune activation leads to immunodeficiency, infections, and cancers
  • 1
    Too much immune activation leads to autoimmune diseases
  • 2
    Not enough immune activation leads to immunodeficiency, infections, and cancers
  • 3
    Unresolved immunity leads to chronic inflammation, immunosuppression, and immune exhaustion
Portfolio

10 First-in-Class Lead Programs

About the multi-modality portfolio

RS is led by a multi-disciplinary team of drug discovery, data science, and venture capital veterans who have founded, built, and led biotech companies worth billions. The internal RS leadership team plays three important roles: 1) They lead end-to-end drug discovery for all RS companies and their drug programs; 2) They assemble and manage large teams of external researchers and drug discovery specialists; and 3) They build and lead valuable research and technology platform capabilities designed to empower all RS companies.

Therapeutic Strategies

Novel Mechanisms Unlock Significant Therapeutic Opportunity

For Autoimmune & Inflammatory Diseases

RS is led by a multi-disciplinary team of drug discovery, data science, and venture capital veterans who have founded, built, and led biotech companies worth billions. The internal RS leadership team plays three important roles: 1) They lead end-to-end drug discovery for all RS companies and their drug programs; 2) They assemble and manage large teams of external researchers and drug discovery specialists; and 3) They build and lead valuable research and technology platform capabilities designed to empower all RS companies.

Extinguishing the “Pilot Light”

Disease State

Danger signals drive & sustain bad autoimmune activation cycles

Healthy State

The root danger signal is removed allowing autoimmunity and inflammation to come to a rest

Extinguishing the “Pilot Light”

Inhibit overactive danger sensing from activating inflammatory alarm signals
Inhibit receipt of the cytokine alarm signals that amplify and sustain local auto-immunity
Increase clearance or editing of byproducts from self to prevent them from triggering danger sensors

For Immune Oncology (IO)

RS is led by a multi-disciplinary team of drug discovery, data science, and venture capital veterans who have founded, built, and led biotech companies worth billions. The internal RS leadership team plays three important roles: 1) They lead end-to-end drug discovery for all RS companies and their drug programs; 2) They assemble and manage large teams of external researchers and drug discovery specialists; and 3) They build and lead valuable research and technology platform capabilities designed to empower all RS companies.

“Rebooting” the Tumor Microenvironment

Suppressed & Exhausted

Ongoing danger signaling leads to immune exhausted, immuno-suppressive, and cancer-growth-favorable tumor micro-environments

Responsive

Precision inhibitors and activators target specific high-leverage mechanisms that can repolarize the microenvironment back to immunotherapy-responsive states

Therapeutic Mechanisms Targeted

Precisely Inhibit the chronic danger signals that cause tumor microenvironments to become exhausted and immunosuppressive
Potently activate cytosolic danger sensors to induce system states that favor acute T-cell-mediated killing of cancer cells

World-Class R&D Led by Over 100 Specialists

20 Luminary Scientific Founders and Leads

RS is led by a multi-disciplinary team of drug discovery, data science, and venture capital veterans who have founded, built, and led biotech companies worth billions. The internal RS leadership team plays three important roles: 1) They lead end-to-end drug discovery for all RS companies and their drug programs; 2) They assemble and manage large teams of external researchers and drug discovery specialists; and 3) They build and lead valuable research and technology platform capabilities designed to empower all RS companies.

Adam Kolom
Co-Founder and Partner, CEO
Adam Kolom
Co-Founder and Partner, CEO

Adam Kolom is a biotech entrepreneur and private equity investor. Adam co-founded and led two of the world’s largest cancer immunotherapy research initiatives and has overseen more than $850 million in biotechnology and healthcare investments. Prior to founding Related Sciences, Adam co-founded Sean Parker’s $250 million nonprofit, the Parker Institute for Cancer Immunotherapy, where he worked closely with Sean designing the Institute, assembling its network of centers, building its roster of scientific talent, and leading over 40 biopharma partnerships.  Before PICI, Adam was Managing Director of the Cancer Research Institute's venture capital fund and global clinical trials program, a member of the healthcare private equity team at General Atlantic, and a management consultant at McKinsey & Company. Adam graduated with honors from the Wharton School at UPenn with a degree in finance and economics.

Jack Milwid
Co-Founder and Partner, President
Jack Milwid
Co-Founder and Partner, President

Jack Milwid is a scientist, entrepreneur, and investor. As a founder of biotech companies worth billions, Jack has led R&D teams, invented platform technologies, and set strategy to create the next generation of life-saving medicines for patients. Prior to founding Related Sciences, Jack was a Principal at Flagship Pioneering, where he was a founder of the cell and gene therapy company Sana Biotechnology (SANA), a founder and leader of R&D for the targeted gene therapy company Cobalt Biomedicine, and the founding head of strategy for the microbiome therapeutics company Kaleido Biosciences. Before Flagship, Jack was an entrepreneur at Third Rock Ventures where he cofounded cancer neoantigen vaccine pioneer, Neon Therapeutics. Jack has a PhD in Health Sciences and Technology from Harvard and MIT.

Brian Albrecht
Partner, Head of Drug Discovery
Brian Albrecht
Partner, Head of Drug Discovery

Brian Albrecht is a 20-year seasoned drug discovery scientist who has led discovery efforts for a multitude of therapeutic programs and helped to launch biotech companies worth billions. Prior to his leadership role at Related Sciences, Brian was a principal at Third Rock Ventures where he was a key founding contributor to several biotech companies including multi-billion-dollar biotech, Relay Therapeutics, and led large drug discovery teams at multiple significant biopharma companies including Rheos Medicines, Constellation Pharmaceuticals, and Amgen. Brian holds a PhD in chemistry from Colorado State University.

Matt Goldstein
Partner, Head of Translational and Clinical Research
Matt Goldstein
Partner, Head of Translational and Clinical Research

Matt Goldstein is a physician-scientist and entrepreneur. He has founded companies, built R&D teams, and led strategy and execution of both pre-clinical research and clinical development. Prior to joining the partnership at Related Sciences, Matt was an entrepreneur at Third Rock Ventures where he spent a decade building and operating Third Rock portfolio companies. He was responsible for building and leading the Immunology program at Tango Therapeutics, the centerpiece of Tango’s strategic multi-billion-dollar partnership with Gilead Sciences, Inc. He also served as the development head for Tango’s lead program which entered the clinic in 1H 2022. Matt was a co-founder of Neon Therapeutics leading Translational Medicine and Early Development through completion of their first clinical study and initial public offering. He is a graduate of Swarthmore College and the MD/PhD program at Stanford University, where he pioneered novel cancer immunotherapies in the lab of Ron Levy, MD. He completed his clinical training in Internal Medicine at Harvard Medical School, Brigham & Women’s Hospital.

Eric Czech
Partner, Head of Data Science
Eric Czech
Partner, Head of Data Science

Eric is a veteran machine learning platform architect specializing in immuno-informatics and statistical genetics.  Prior to Related Sciences, he engineered data pipelines at Bridgewater, led the development of infrastructure and predictive analytics products at music and insurance companies, and published statistical methods for high-throughput single-cell as well as multiplexed immunological imaging assays at HammerLab.  He graduated with a BS degree in Computer Science and Applied Mathematics from Brown University.

Jeff Hammerbacher
Co-Founder
Jeff Hammerbacher
Co-Founder

Jeff Hammerbacher is a scientist, software developer, entrepreneur, and investor. Jeff has founded and led teams that have produced dozens of scientific publications with hundreds of citations per year, 3 of the world's most popular open source database systems, over 100 angel investments, and a public company with a market capitalization of several billion dollars. Prior to founding Related Sciences, Jeff was the Principal Investigator of Hammer Lab, a founder and the Chief Scientist of Cloudera, an Entrepreneur-in-Residence at Accel, the manager of the Data team at Facebook, and a quant at Bear Stearns. In addition to his work at Related Sciences, Jeff is an angel investor with Techammer and is a board member at Ciox and Cytel. Jeff has a bachelor's degree in Mathematics from Harvard University.

Swathi Boppana
Research Analyst
Swathi Boppana
Research Analyst

Swathi is an analyst on the Related Sciences research team, based in India.  She has a bachelor’s degree in pharmacy, a master’s of business administration in health care services, and is a registered pharmacist.  She has previously held contract positions at Thomson Reuters as an associate research analyst, at Amazon as a pharma associate and subject matter expert, and most recently worked at Alliantgroup as a medical analyst.

Jess Elman
Head of Clinical Strategy
Jess Elman
Head of Clinical Strategy

Jess Elman is a cellular and molecular biologist with deep expertise in preclinical models and drug development. Prior to Related Sciences Jess was a Senior Scientist at Sana Biotechnology where she helped bring several immuno-oncology therapeutics from early concept to IND enabling studies. Jess completed her PhD in Cell, Molecular and Developmental Biology at Tufts University.

Brett Treacy
Controller
Brett Treacy
Controller

Brett Treacy is a seasoned Financial Controller with broad-based accounting, finance, and analytical experience from senior roles in private equity, biotech, and public accounting firms. Prior to Related Sciences, Brett served as an external Controller for multiple startup biotech companies while working at Danforth Advisors.  Brett previously also served as the Associate Director of Finance for Accent Therapeutics, the Director of Financial Planning and Analysis at Mondo, the Controller at Equity Resource Investments, and an Accounting Manager at Prague & Company. In these roles, Brett has been instrumental in building out multiple companies’ financial organizations, ensuring accurate and timely reporting of metrics, and providing growth-enabling leadership. Brett is currently completing his Master of Science in Taxation from Northeastern University and graduated with a Bachelor of Applied Science in Finance from Oakland University.

Penny Feng
Translational Biology Lead
Penny Feng
Translational Biology Lead

Penny is a cancer biologist with extensive background in small molecule drug discovery, pharmacology, and translation.  Prior to joining Related Sciences, Penny was a senior scientist at Tango Therapeutics. She led the biology efforts for a key drug discovery program from conception to IND-enabling stage. Prior to Tango Therapeutics, Penny was a presidential postdoctoral fellow at Novartis Institutes for BioMedical Research. Penny holds a DPhil from University of Oxford, having trained in the laboratory of Prof. Sir Peter Ratcliffe.

Mike Morrison
Head of Molecular Discovery
Mike Morrison
Head of Molecular Discovery

Mike Morrison is a 17-year veteran of the biotechnology industry focusing on small-molecule drug discovery.  As an enzymologist, he has extensive experience in high-throughput screening, hit identification, and characterization of enzyme inhibitors.  Prior to Related Sciences, Mike was the head of Lead Discovery at Rheos Medicines where he directed all aspects of biochemistry, biophysics, structural biology, and cell pharmacology.  Prior to Rheos, Mike held positions at Epizyme, Ambit Biosciences, and Amgen.   Mike graduated from Wesleyan University with a BA/MA and holds a PhD in biological chemistry from MIT.

Dana Foss
Head of Therapeutic Technologies
Dana Foss
Head of Therapeutic Technologies

Dana Foss is a protein and RNA biochemist with extensive experience in genome editing, RNA silencing, and delivery of therapeutic macromolecules. Prior to Related Sciences Dana was a postdoctoral researcher at UC Berkeley supervised by Ross Wilson and Jennifer Doudna, where she engineered new methods of delivering CRISPR-Cas9 into human immune cells as a biological therapeutic.  Dana holds a PhD in Biochemistry from the University of Ottawa.

Daniel Himmelstein
Head of Data Integration
Daniel Himmelstein
Head of Data Integration

Daniel Himmelstein is a leading data scientist focused on integrating large scale omics data, turning biological knowledge into machine-optimized networks and databases.  Prior to Related Sciences, Daniel created several projects to advance computational methods for biomedical knowledge including Hetionet and Manubot. Hetionet is an open-source network that combines data from 29 resources and millions of studies to capture the knowledge from decades of biomedical research. Manubot is a system for open writing on GitHub, allowing authors from around the world to collaborate in a transparent and automated manner. Daniel received his PhD in Biological & Medical Informatics from the University of California, San Francisco. As an undergraduate at Cornell University, he majored in Biometry & Statistics.

https://github.com/dhimmel

Daniela Grinis
Research Associate
Daniela Grinis
Research Associate

Daniela Grinis is a researcher focused on molecular biology and cloning.  Prior to RS, Daniela was a part of a CRISPR screening team working with bacterial and mammalian tissue culture to identify impactful enzymes for translation into therapeutic products, and a member of a microbiology lab that studied DNA repair and recombination mechanisms in E.coli using a range of molecular cloning techniques. Daniela graduated from the University of Massachusetts Amherst with a Bachelor of Science in Biology.

Morgan Languirand
Research Associate
Morgan Languirand
Research Associate

Morgan Languirand is a scientific researcher specializing in molecular biology. Prior to Related Sciences, Morgan was part of a molecular diagnostic team focused on analyzing post TMA-PCR tests for COVID-19. Morgan graduated from the University of New Hampshire with a Bachelor of Science in Biology.

Melinda Lyman-Wright
Operational HR (Danforth)
Melinda Lyman-Wright
Operational HR (Danforth)

Melinda is an HR specialist that supports related Sciences through Danforth consulting.

Ilya Rahkovsky
Senior Data Scientist
Ilya Rahkovsky
Senior Data Scientist

Ilya Rahkovsky is an experienced Data Scientist specializing in emerging technology and scientometrics. He previously worked as a Data Scientist at the CSET where he led the development of the Science Map (https://sciencemap.cset.tech), technology forecasting, and studies of venture capital investment. Before that Ilya was working as a senior research economist at the Economics Research Service of USDA modeling demand and information use by consumers. Ilya has a Phd in Economics from the Michigan State University and taught Statistics and Machine Learning at the Johns Hopkins University.

Rafał Wojdyła
Head of Data Engineering
Rafał Wojdyła
Head of Data Engineering

Rafał Wojdyła specializes in data engineering.  Prior to Related Sciences Rafal worked at Spotify on data storage, processing and machine learning, and helped to build the largest processing cluster in Europe as well as a range of open and closed source libraries.  Rafal graduated from the AGH University of Science and Technology with a degree in Computer Science.

Led by Related Sciences and powered by the RS platform

References

1: Citeline/BIO/QLS - Clinical Development Success Rates and Contributing Factors 2011-2020; https://pharmaintelligence.informa.com/resources/product-content/2021-clinical-development-success-rates

2: RS cohort analysis of 2,776 Therapeutics biotechs founded between 2007 and 2016, integrated data from RS Facets data platform leveraging primary data from many sources including Informa, Cortellis, DealForma, and Factset.

3: Related Sciences analysis of institutional investor participation in the Therapeutics biotech sector leveraging integrated data sets from RS Facets data platform.

4: Based on proprietary evaluation of hundreds of millions of target-disease pairs within the RS Facets global ranking pipeline.

5: RS proprietary ontology of risk in biotech.